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The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
This app note presents a complete high-throughput workflow solution for sequence mapping analysis.
This app note presents a high-throughput workflow that enables simultaneous, highly reproducible sample digestion and cleanup.
Comparative analysis using LC-QTOF/MS between innovator and biosimilar of Rituximab
This Application note demonstrates peptide mapping of a therapeutic mAb using Agilent 1260 Bio-inert Quaternary LC with fusion QbD method development software.
Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
The Agilent AdvanceBio Peptide Mapping column separates mAb tryptic digests at low system pressures, providing UHPLC performance from HPLC operating conditions.
| Publication Part Number | 5991-3585EN | |||
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Peptide mapping is the common analytical technique for characterizing biologic therapeutic proteins.
| Publication Part Number | 5991-3600EN | ||||
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The AdvanceBio Peptide Mapping column gives 100% rhEPO sequence coverage with 45 glycopeptide matches.
| Publication Part Number | 5991-1813EN | |||
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