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This application note demonstrates the resolution and robustness made possible with an Agilent TED in combination with an Agilent 1290 Infinity II Bio LC at elevated temperatures.
The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
A guide to find the right column for your characterization workflow. It includes advice and tips on method development, solvent choice, mobile phase modification, optimization, example separations, as well as ordering information.
Application note for MS of AAV CQAs
Critical Quality Attributes Peptide Mapping compendium
Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
This app note presents a complete high-throughput workflow solution for sequence mapping analysis.
This app note presents a high-throughput workflow that enables simultaneous, highly reproducible sample digestion and cleanup.
Comparative analysis using LC-QTOF/MS between innovator and biosimilar of Rituximab
This Application note demonstrates peptide mapping of a therapeutic mAb using Agilent 1260 Bio-inert Quaternary LC with fusion QbD method development software.
Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
An Agilent 2.7 μm HILIC column revealed a glycopeptide not seen by RP. HILIC can be orthogonal and complementary to RP for better retention of hydrophilic peptides.
This Application Note shows the workflow solution for the physicochemical and biological characterization of a biosimilar and innovator rituximab.
The Agilent AdvanceBio Peptide Mapping column separates mAb tryptic digests at low system pressures, providing UHPLC performance from HPLC operating conditions.
| Publication Part Number | 5991-3585EN | |||
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Peptide mapping is the common analytical technique for characterizing biologic therapeutic proteins.
| Publication Part Number | 5991-3600EN | ||||
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The AdvanceBio Peptide Mapping column gives 100% rhEPO sequence coverage with 45 glycopeptide matches.
| Publication Part Number | 5991-1813EN | |||
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This peptide mapping “how-to” helps you optimize your peptide mapping separations to achieve the best possible results.