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This application note presents the SEC method, coupled with LC/UV and LC/Q-TOF, to study the oligomeric states of liraglutide.
- Publication Part Number: 5994-8398EN
- Created: 23 May 2025
- 645 KB
Guidance for choosing the appropriate pore size column for oligonucleotide separation by size exclusion chromatography.
- Publication Part Number: 5994-8198EN
- Created: 12 Mar 2025
- 528 KB
Comparison of SEC columns for aggregate analysis of AAVs
- Publication Part Number: 5994-7918EN
- Created: 08 Nov 2024
- 360 KB
The Agilent AdvanceBio SEC column together with the Agilent 1260 Infinity II Bio-inert System is an ideal combination for the aggregate analysis of ADCs
- Publication Part Number: 5991-8244EN
- Created: 15 Oct 2024
- 811 KB
Aggregate analysis of adeno-associated viruses with AdvanceBio SEC 500 ? columns
- Publication Part Number: 5994-7509EN
- Created: 28 May 2024
- 729 KB
Aggregate analysis of a ~50 nm virus-like particle using an AdvanceBio SEC 1000? column.
- Publication Part Number: 5994-7427EN
- Created: 22 May 2024
- 330 KB
GPC/SEC analysis of gelatin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns.
- Publication Part Number: 5994-6270EN
- Created: 01 Aug 2023
- 1 MB
GPC/SEC analysis of human insulin in water/acetic acid/acetonitrile/L-Arginin using Agilent PROTEEMA columns.
- Publication Part Number: 5994-6259EN
- Created: 01 Aug 2023
- 1 MB
GPC/SEC analysis of gelatin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns.
- Publication Part Number: 5994-6269EN
- Created: 01 Aug 2023
- 2 MB
The enzyme l-asparaginase poses a challenge for quantifying aggregation as its structure may produce high molecular weight aggregates.
- Publication Part Number: 5994-6587EN
- Created: 28 July 2023
- 543 KB
Agilent AdvanceBio SEC columns are specifically designed for aqueous size exclusion chromatography (SEC) of biomolecules.
- Publication Part Number: 5991-7799EN
- Created: 05 July 2023
- 1 MB
GPC/SEC analysis of low molecular weight heparin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns according to EU pharmacopeia.
- Publication Part Number: 5994-6319EN
- Created: 01 July 2023
- 1 MB
This application brief describes the GPC/SEC analysis of monoclonal antibodies (mAb) to determine the content and size of aggregates and fragments.
- Publication Part Number: 5994-5721EN
- Created: 02 Mar 2023
- 223 KB
This application brief illustrates the GPC/SEC analysis of proteins from medium to high molecular weight using an Agilent PROTEEMA column.
- Publication Part Number: 5994-5728EN
- Created: 02 Mar 2023
- 152 KB
This application brief illustrates the GPC/SEC analysis of proteins from low to medium molecular weight using an Agilent PROTEEMA column.
- Publication Part Number: 5994-5727EN
- Created: 02 Mar 2023
- 155 KB
Aggregate and Fragment Analysis of Adeno-Associated Viral Vectors using Size Exlusion is a critical analysis. Bio SEC-5 demonstrates reproducible separation and resolution of these AAV particles and aggregates.
- Publication Part Number: 5994-4270EN
- Created: 27 Oct 2021
- 454 KB
Virus-like particles (VLPs) are highly structured protein particles that are self-assembled from one or more structural proteins, typically 20 to 150 nm in diameter.
- Publication Part Number: 5994-4227EN
- Created: 29 Sep 2021
- 194 KB
An SEC method identifying innovator and biosimilar insulin analog was developed using an Agilent AdvanceBio SEC 130?, 7.8 × 300 mm, 2.7 μm column.
- Publication Part Number: 5991-6872EN
- Created: 12 May 2021
- 513 KB
Evaluation of SEC Columns for Analysis of ADC Aggregates and Fragments - Choosing the best stationary phase to overcome nonspecific interactions.
- Publication Part Number: 5994-3276EN
- Created: 11 May 2021
- 376 KB
This collection of 10 Agilent ‘a(chǎn)ggregate and fragment analysis’ app notes also includes our guide on how to perform SEC for biomolecule analysis.
- Publication Part Number: 5994-0032EN
- Created: 01 Apr 2021
- 7 MB