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This application note presents the SEC method, coupled with LC/UV and LC/Q-TOF, to study the oligomeric states of liraglutide.
Guidance for choosing the appropriate pore size column for oligonucleotide separation by size exclusion chromatography.
Accurately determine biomolecule aggregation and fragmentation with Agilent size exclusion columns.
Comparison of SEC columns for aggregate analysis of AAVs
The Agilent AdvanceBio SEC column together with the Agilent 1260 Infinity II Bio-inert System is an ideal combination for the aggregate analysis of ADCs
Aggregate analysis of adeno-associated viruses with AdvanceBio SEC 500 ? columns
Aggregate analysis of a ~50 nm virus-like particle using an AdvanceBio SEC 1000? column.
A guide to find the right column for your characterization workflow. It includes advice and tips on method development, solvent choice, mobile phase modification, optimization, example separations, as well as ordering information.
GPC/SEC analysis of gelatin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns.
GPC/SEC analysis of human insulin in water/acetic acid/acetonitrile/L-Arginin using Agilent PROTEEMA columns.
GPC/SEC analysis of gelatin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns.
The enzyme l-asparaginase poses a challenge for quantifying aggregation as its structure may produce high molecular weight aggregates.
Agilent AdvanceBio SEC columns are specifically designed for aqueous size exclusion chromatography (SEC) of biomolecules.
GPC/SEC analysis of low molecular weight heparin in an aqueous phosphate buffer solution using Agilent PROTEEMA columns according to EU pharmacopeia.
This application brief describes the GPC/SEC analysis of monoclonal antibodies (mAb) to determine the content and size of aggregates and fragments.
This application brief illustrates the GPC/SEC analysis of proteins from medium to high molecular weight using an Agilent PROTEEMA column.
This application brief illustrates the GPC/SEC analysis of proteins from low to medium molecular weight using an Agilent PROTEEMA column.
Aggregate and Fragment Analysis of Adeno-Associated Viral Vectors using Size Exlusion is a critical analysis. Bio SEC-5 demonstrates reproducible separation and resolution of these AAV particles and aggregates.
Virus-like particles (VLPs) are highly structured protein particles that are self-assembled from one or more structural proteins, typically 20 to 150 nm in diameter.
PEEK-lined columns and bio-inert supplies to complement the Agilent 1290 Infinity II Bio LC system