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Technical overview describing ion exchange method development and troubleshooting
Agilent AdvanceBio spin columns to desalt fractions from oligonucleotide purification.
This application note highlights excellent performance of Agilent PL-SAX columns for synthetic oligonucleotide analysis and suggests an optimal kickoff for exploring alternative method conditions.
PLRP-S reversed-phase HPLC columns deliver the pure oligonucleotides required for genomic applications.
Oligonucleotide analysis with ion-pairing-free reversed phase method and TOF LC/MS
Direct 2D-LC analysis of oligonucleotides in solution with high salt content, with online desalting in the first dimension and IP-RPLC in the second dimension.
This user guide describes how to calculate the amount of PL-SAX media needed to pack a column. It briefly describes best practices for loading the column.
From analytical to preparative scale, Agilent AdvanceBio Oligonucleotide columns, software, and instrumentation pair seamlessly to minimize method optimization and downtime.
AdvanceBio superficially porous columns for excellent performance and resolution for semi-prep purification of synthetic oligos without compromising column loading.
In this application note, we explore some of the key parameters when comparing different column chemistries using ion-pair reversed-phase (IP-RP) separation of Semaglutide.
Consumables workflow ordering guide for oligonucleotide purification using ion pair reversed-phase liquid chromatography.
Easily find all you need for oligonucleotide purification using anion exchange liquid chromatography with this workflow ordering guide.
Quick and efficient sample cleanup for biomolecule analysis using AdvanceBio spin cartridges and Gly-X InstantPC labeling
In this application note, we explore some of the key parameters when developing an ion-pair reversed-phase (IP-RP) separation of mRNA.
Molecular weight confirmation and simple characterization workflows for synthetic oligos with Agilent LC/MSD XT and MS Spectral Deconvolution feature in OpenLab CDS 2.8.
End-to-End Workflow Solutions for Oligonucleotide Analysis. From research discovery to production QA/QC.
Polymeric particles, such as PLRP-S and PL-SAX, are ideal for analyzing and purifying oligonucleotides. Because these materials are thermally and chemically stable, they enable diverse techniques.
A guide to find the right column for your characterization workflow. It includes advice and tips on method development, solvent choice, mobile phase modification, optimization, example separations, as well as ordering information.
This application note demonstrates the utility of Agilent Bio SAX columns for oligonucleotide analysis and provides suggested starting points for further method development.
Information and tips on installing and using Agilent PLRP-S, PL-SAX, and PL-SCX preparative LC columns