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The Agilent AdvanceBio SEC column together with the Agilent 1260 Infinity II Bio-inert System is an ideal combination for the aggregate analysis of ADCs
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
Describes a comparison between the Agilent AdvanceBio SEC 200 ? 1.9 μm column and other vendors' SEC columns in terms of mAb and ADC analysis.
Agilent AdvanceBioSEC columns used for fast, high resolution, sensitive, and reproducible separation and quantitation of mAbs and Antibody Drug Conjugate,
Simple, sensitive SEC quantitates aggregates in biotherapeutic mAb and ADC with the same aqueous eluent, without organic, on a bioinert LC and AdvanceBio SEC column.