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Identification of monoclonal antibody mutation sites using the 1290 Infinity II 2D-LC solution with 6530 Q-TOF LC/MS.
In this application note, we explore some of the key parameters when comparing different column chemistries using ion-pair reversed-phase (IP-RP) separation of Semaglutide.
Brochure on AdvanceBio RP-mAb columns for large molecule characterization.
This application note describes multi-attribute analysis of monoclonal antibodies using the Agilent InfinityLab 2D-LC Solution and the Agilent 6530 LC/Q-TOF system.
Presents the use of the AdvanceBio HIC column to resolve monoclonal antibody variants from their native form without mAb digestion into subunits.
Presents a method for peptide mapping using an Agilent LC/MSD XT and 1290 Infinity II LC.
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Describes the use of the new AdvanceBio HIC column, with method optimization, to assess DAR values of ADCs.
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
Agilent PLRP-S column demonstrates superior separation performance for the analysis of mAbs and ADC at both intact and fragment levels
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
In this paper, we are investigating an antibody drug conjugate (ADC) with a cysteine linker.
Analyzing therapeutic mAbs with AdvancedBio RP-mAb and a 6530 Accurate-Mass Q-TOF LC/MS delivers fast and high-resolution separation of intact and ADC mAbs.
"Fast and High Resolution Analysis of Intact and Reduced Therapeutic Monoclonal Antibodies (mAbs) using the Agilent Bio-inert LC and AdvanceBio RP-mAb Columns
Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
Agilent Bio Mab WCX separates charged variants of papain-digest monoclonal antibody, following by MS characterization of the charged variants with online desalting.
An Agilent Bio-Monolith Protein A column determined recombinant mAb titer and was used to enrich μg amounts of antibody for further structural characterization by MS.
The charge heterogeneity provides a great challenge for the complete characterization of the monoclonal antibody (mAb).
This work describes a high flow LCMS method to demonstrate the high resolution mass analysis of mAbs with good chromatography and its utility in analysis of Biosimilar mAbs.
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