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Agilent Bio-Monolith Protein G quantitates supernatant mAbs across a wide loading range at many flow rates, complementing Protein A for fast titer analysis.
An SEC method identifying innovator and biosimilar insulin analog was developed using an Agilent AdvanceBio SEC 130?, 7.8 × 300 mm, 2.7 μm column.
This application note describes multi-attribute analysis of monoclonal antibodies using the Agilent InfinityLab 2D-LC Solution and the Agilent 6530 LC/Q-TOF system.
An aggregate analysis workflow for SEC mobile phase optimization and characterization of mAb aggregation profiles
"This Application Note describes the quantification of aggregates in biotherapeutic
Achieve true high-definition separations without sacrificing stability with Agilent ZORBAX Rapid Resolution High Definition columns.
AdvanceBio Desalting - RP cartridges used for effective desalting of LC-separated monoclonal antibodies (mAbs) before characterization by mass spectrometry
Agilent AdvanceBioSEC columns used for fast, high resolution, sensitive, and reproducible separation and quantitation of mAbs and Antibody Drug Conjugate,
A SEC method for determining the purity of PEG Granulocyte Colony Stimulating Factor using an Agilent AdvanceBio SEC column with aqueous mobile phase.
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
Shorter 150 mm AdvanceBio SEC columns and higher flow rates of 1.5 mL/min increase sample throughput by 400%, from 1.3 days to under 8 hours.
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
High resolution and sensitive size exclusion chromatography separates and quantitates rituximab aggregates/degradants in a bioinert LC with an AdvanceBio SEC column.
"Fast and High Resolution Analysis of Intact and Reduced Therapeutic Monoclonal Antibodies (mAbs) using the Agilent Bio-inert LC and AdvanceBio RP-mAb Columns
Biomolecule Characterization workflow. Agilent Bio-Monolith Protein A and G Affinity columns. and 1260 Infinity Bio-Inert LC System.
Anion Exchange Chromatography with Agilent Bio HPLC columns and 1260 Infinity Bio-Inert LC System
Reversed-phase LC primary structure characterization workflow using Agilent AdvanceBio RP-mAb columns and Agilent 1260 Infinity Bio-Inert LC system
Now you have more columns and more choices to improve your charged-variant analysis of proteins with the Agilent Ion-exchange BioHPLC columns.
The Agilent 1290 Infinity 2D-LC Solution identifies peptides and proteins in top-down and bottom-up proteomics with the same configuration for automatic method transfer.
This Application Note shows the workflow solution for the physicochemical and biological characterization of a biosimilar and innovator rituximab.