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Technical overview describing ion exchange method development and troubleshooting
Agilent AdvanceBio spin columns to desalt fractions from oligonucleotide purification.
This application note highlights excellent performance of Agilent PL-SAX columns for synthetic oligonucleotide analysis and suggests an optimal kickoff for exploring alternative method conditions.
This application note details the results from analyzing tirzepatide and its related impurities under varying pH and storage conditions.
Oligonucleotide analysis with ion-pairing-free reversed phase method and TOF LC/MS
This Application Note describes a simple method for the analysis of disulfide linkages in monoclonal antibodies (mAbs) by reversed phase HPLC.
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Direct 2D-LC analysis of oligonucleotides in solution with high salt content, with online desalting in the first dimension and IP-RPLC in the second dimension.
This user guide describes how to calculate the amount of PL-SAX media needed to pack a column. It briefly describes best practices for loading the column.
From analytical to preparative scale, Agilent AdvanceBio Oligonucleotide columns, software, and instrumentation pair seamlessly to minimize method optimization and downtime.
AdvanceBio superficially porous columns for excellent performance and resolution for semi-prep purification of synthetic oligos without compromising column loading.
In this application note, we explore some of the key parameters when comparing different column chemistries using ion-pair reversed-phase (IP-RP) separation of Semaglutide.
Consumables workflow ordering guide for oligonucleotide purification using ion pair reversed-phase liquid chromatography.
In this application note, we explore some of the key parameters when developing an ion-pair reversed-phase (IP-RP) separation of mRNA.
Molecular weight confirmation and simple characterization workflows for synthetic oligos with Agilent LC/MSD XT and MS Spectral Deconvolution feature in OpenLab CDS 2.8.
This user guide compendium summarizes the different types of LC guard columns and how to install them.
Competitive comparison from analytical to semipreparative purification of synthetic oligonucleotides.
This poster covers columns for oligonucleotide chromatography, from siRNA/ASO to mRNA.